When planning a beach getaway for a larger group, East Islands Rentals is here to help. We have a diverse selection of Isle of Palms vacation rentals with 5 bedrooms or more. With homes that accommodate up to 13 guests, there is space and privacy for your group. These larger homes are perfect for those planning a family reunion, a multi-family vacation, a girlfriend’s getaway, or even a corporate retreat.

Each of our vacation rentals feature a well-equipped kitchen, spacious dining areas, large living areas, and fantastic outdoor spaces. Most homes offer expansive decks for dining al fresco or sunbathing.

Browse our selection of Isle of Palms vacation rentals with 5 bedrooms or more, and find one perfect for your South Carolina getaway.

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610 OCEAN | OCEANFRONT | SEASIDE BEAUTY | POOL FROM $2385 - $3700

610 OCEAN | OCEANFRONT | SEASIDE BEAUTY | POOL

Isle Of Palms
Beds: 11 | Baths: 8 | Sleeps: 28
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11-55TH AVE | OCEANFRONT | BEACH DAYS | SCREEN PORCH | FROM $500 - $1700

11-55TH AVE | OCEANFRONT | BEACH DAYS | SCREEN PORCH |

Isle of Palms
Beds: 6 | Baths: 5 | Sleeps: 16
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902 OCEAN | OCEANFRONT | OCEAN CAMP | POOL | SPA FROM $570 - $2121

902 OCEAN | OCEANFRONT | OCEAN CAMP | POOL | SPA

Isle of Palms
Beds: 6 | Baths: 4 | Sleeps: 14
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9 BEACHWOOD W |  OCEAN VIEW | WHISPERING OAKS FROM $285 - $1107

9 BEACHWOOD W | OCEAN VIEW | WHISPERING OAKS

Isle of Palms
Beds: 5 | Baths: 3.5 | Sleeps: 12
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216 OCEAN | OCEANFRONT | BEACH HOUSE | SCREEN PORCH | ELEVATOR FROM $570 - $1778

216 OCEAN | OCEANFRONT | BEACH HOUSE | SCREEN PORCH | ELEVATOR

Isle of Palms
Beds: 7 | Baths: 5 | Sleeps: 16
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612 OCEAN | OCEANFRONT | BELLA VISTA |POOL | SPA | ELEVATOR FROM $820 - $2850

612 OCEAN | OCEANFRONT | BELLA VISTA |POOL | SPA | ELEVATOR

Isle of Palms
Beds: 7 | Baths: 5.5 | Sleeps: 16
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110 OCEAN |OCEANFRONT | FIREFLY | POOL | ELEVATOR FROM $1271 - $4355

110 OCEAN |OCEANFRONT | FIREFLY | POOL | ELEVATOR

Isle of Palms
Beds: 10 | Baths: 11 | Sleeps: 28
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2201 PALM | THE SURF SHACK | POOL | HOT TUB FROM $358 - $1192

2201 PALM | THE SURF SHACK | POOL | HOT TUB

Isle of Palms
Beds: 5 | Baths: 5 | Sleeps: 10
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812 OCEAN | OCEANFRONT | LANDS END | POOL | SPA | ELEVATOR FROM $1278 - $3417

812 OCEAN | OCEANFRONT | LANDS END | POOL | SPA | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 6.5 | Sleeps: 12
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3000 PALM | OCEANFRONT | SAND PIT | SCREEN PORCH | ELEVATOR FROM $607 - $1807

3000 PALM | OCEANFRONT | SAND PIT | SCREEN PORCH | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 6 | Sleeps: 12
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108 OCEAN | OCEANFRONT | LADY POSEIDON | POOL | SPA | ELEVATOR FROM $892 - $2785

108 OCEAN | OCEANFRONT | LADY POSEIDON | POOL | SPA | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 5.5 | Sleeps: 18
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3706 CAMERON | OCEANVIEW | ATTITUDE ADJUSTMENT | POOL | ELEVATOR FROM $395 - $1542

3706 CAMERON | OCEANVIEW | ATTITUDE ADJUSTMENT | POOL | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 4.5 | Sleeps: 12
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2916 PALM | OCEANFRONT | PALM BREEZE | POOL | SPA | ELEVATOR FROM $842 - $2714

2916 PALM | OCEANFRONT | PALM BREEZE | POOL | SPA | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 6.5 | Sleeps: 16
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908 OCEAN | OCEANFRONT | BISHOPS | POOL | ELEVATOR FROM $890 - $2800

908 OCEAN | OCEANFRONT | BISHOPS | POOL | ELEVATOR

Isle of Palms
Beds: 7 | Baths: 5.5 | Sleeps: 14
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12 GRAND PAVILION | OCEANVIEW | SUNSHINE BY THE SEA | COMM. POOL FROM $564 - $1570

12 GRAND PAVILION | OCEANVIEW | SUNSHINE BY THE SEA | COMM. POOL

Isle of Palms
Beds: 6 | Baths: 4.5 | Sleeps: 14
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816 OCEAN | OCEANFRONT | SAND SERENITY | POOL | SPA | ELEVATOR FROM $1275 - $3592

816 OCEAN | OCEANFRONT | SAND SERENITY | POOL | SPA | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 7 | Sleeps: 12
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604 OCEAN | OCEANFRONT | C BREEZE | POOL | ELEVATOR FROM $840 - $3414

604 OCEAN | OCEANFRONT | C BREEZE | POOL | ELEVATOR

Isle of Palms
Beds: 8 | Baths: 9 | Sleeps: 19
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312 OCEAN | OCEANFRONT | OCEAN ESCAPE | POOL | ELEVATOR FROM $640 - $2242

312 OCEAN | OCEANFRONT | OCEAN ESCAPE | POOL | ELEVATOR

Isle of Palms
Beds: 6 | Baths: 4 | Sleeps: 14
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5 DUNECREST |  OCEANFRONT | VIEWS | ELEVATOR FROM $815 - $2071

5 DUNECREST | OCEANFRONT | VIEWS | ELEVATOR

Isle of Palms
Beds: 5 | Baths: 5.5 | Sleeps: 12
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410 CAROLINA | OCEAN VIEW | CAROLINA DREAM | POOL | ELEVATOR FROM $427 - $1985

410 CAROLINA | OCEAN VIEW | CAROLINA DREAM | POOL | ELEVATOR

Isle of Palms
Beds: 5 | Baths: 5 | Sleeps: 13
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906 OCEAN | OCEANFRONT | PELICAN WATCH | VIEW DECK FROM $564 - $1821

906 OCEAN | OCEANFRONT | PELICAN WATCH | VIEW DECK

Isle of Palms
Beds: 5 | Baths: 3 | Sleeps: 12
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